How does CBD interact with other medications?
As CBD gains popularity for its many therapeutic virtues, it is essential to question its possible repercussions on cardiovascular health. The question of cardiac contraindication with CBD is attracting growing interest among health professionals and consumers, anxious to preserve their cardiac well-being while exploring the potential benefits of cannabidiol. This awareness marks a turning point in the global approach to well-being, highlighting the importance of caution and precise information regarding food and drug supplements.
This article strives to provide a comprehensive overview of the current knowledge on CBD, with a focus on the potential risks it may pose to individuals with cardiac conditions. It will address general contraindications of CBD, with a particular focus on the specific cases of cardiac contraindications, while discussing precautions to take before its consumption. In addition, it will explore alternatives to CBD for cardiac patients, ensuring complete and nuanced information. This informed framework will allow readers to better understand the issues surrounding cardiac contraindication with CBD and how to carefully navigate the complex world of CBD, also taking into account its side effects such as drowsiness, for a safer approach to its use.
What is CBD?
Definition and origins
Cannabidiol, more commonly known as CBD, is one of over a hundred phytocannabinoids found in the cannabis plant. 1. Historically, cannabis was one of the first plants cultivated by man, used as early as 8000 BC for its strong fibers and nutritional properties. 2. It was not until the 20th century that CBD was isolated and studied for its specific properties. Roger Adams, a chemist, first isolated CBD in 1940, and it was in 1963 that Raphael Mechoulam determined its molecular structure, confirming that CBD was not a psychoactive 2 .
Common uses
CBD is recognized for its many medical applications, including its anti-inflammatory, analgesic, and anxiolytic effects. 3. It is used to treat various conditions such as chronic pain, epilepsy, anxiety disorders, and more. Cannabis strains high in CBD and low in THC have been developed to maximize these benefits without the psychoactive effects associated with THC. 3. In France, Epidyolex, a CBD-based medication, is authorized for the treatment of certain forms of epilepsy. 4. Despite its potential, CBD is also subject to discussions regarding its regulation and the variability of its composition due to different cultivation and extraction methods. 4 .
Potential Risks of CBD for the Heart
While CBD is often considered for its therapeutic benefits, it is crucial to understand the potential risks it may pose to the heart, particularly regarding inflammation, blood pressure, and arrhythmias.
Effects of CBD on the cardiovascular system
CBD interacts with the endocannabinoid system, which can positively impact cardiovascular health in several ways. First, it is known for its ability to reduce inflammation, a key factor in the breakdown of cardiovascular cells that can lead to serious diseases if left untreated. 5. Additionally, CBD may help lower blood pressure by widening blood vessels, allowing for better blood flow and reducing the risks associated with hypertension. 5 .
However, the role of CBD in treating arrhythmias remains uncertain. Although studies in animal models have shown promising results, the need for further research is crucial to confirm these effects in humans. 5 .
Examples of potential heart-related risks
CBD use is not without risks, particularly due to possible drug interactions that can be particularly concerning for heart patients. It is imperative to consult a doctor before starting a CBD treatment, especially for people suffering from heart disease. 6 .
Research is ongoing to evaluate the anti-inflammatory benefits of CBD in heart disease. However, the current meta-analysis does not yet allow for clear clinical recommendations regarding its use for these indications. 6. Additionally, cases of CBD overconsumption have been reported, leading to serious consequences such as severe arrhythmias, illustrating the need to strictly adhere to dosage recommendations. 7 .
This information highlights the importance of caution in the use of CBD, especially for individuals with existing heart predispositions or conditions.
General contraindications of CBD
Commonly Interacting Drugs
CBD can influence the effectiveness of various medications by inhibiting the enzymes responsible for their metabolism. Among the cytochromes affected are CYP2B6, CYP2C19 and CYP3A4, essential in the transformation of many drug treatments 8. This inhibition may significantly alter plasma concentrations of drugs such as antiepileptics, anticoagulants such as warfarin, and immunosuppressants such as tacrolimus, requiring dosage adjustment to avoid toxicity. 8. Additionally, consuming CBD with medications that can induce drowsiness or alcohol can accentuate this effect, increasing the risk of accidents. 9 .
Pathologies concerned
Certain medical conditions require special care when using CBD. Individuals with liver impairment should be especially cautious, as their ability to metabolize CBD may be compromised, potentially requiring dosage adjustments. 9. Similarly, people with Parkinson's disease may experience worsening of their motor symptoms due to the interaction of CBD with their usual treatment. 10. Additionally, epilepsy patients should consult their doctor before using CBD, as it may interact with antiepileptic medications and alter their effectiveness. 8. Finally, pregnant or breastfeeding women and men wishing to conceive are not advised to use CBD due to preliminary data suggesting a potential impact on fertility. 9 .
Specific cases of cardiac contraindications
Ban on beta blockers
CBD use may pose significant risks when combined with beta-blocker medications. These medications, prescribed for a variety of heart conditions such as high blood pressure and heart failure, work by reducing blood pressure and heart rate. The vasodilatory effect of CBD, which also helps lower blood pressure, may enhance the effects of beta-blockers, potentially causing excessive lowering of blood pressure or abnormal slowing of the heart rate. 11. This interaction could cause dizziness, fainting, or other serious complications in patients. Additionally, CBD is known to inhibit certain liver enzymes, which may impair the metabolism of beta-blockers, increasing their plasma concentration and potentially their toxicity. 11. It is therefore crucial to consult a doctor before combining CBD and beta blockers, and to scrupulously follow medical recommendations to avoid risks.
Interactions with anticoagulants
CBD interactions with blood thinners are also a major concern. Blood thinners, which are used to thin the blood and prevent clots, may have their effectiveness altered by CBD. One study found that CBD may increase the effects and durability of warfarin, a common blood thinner, which can lead to an increased risk of bleeding, especially if there is an injury. 12. This interaction requires close medical monitoring, particularly with regard to blood INR measurements, to ensure that levels remain within a safe range and to adjust the dosage of anticoagulants if necessary. 13. Patients on anticoagulant treatment should discuss with their doctor before starting CBD treatment, in order to assess the risks and adjust treatment accordingly.
Precautions to take before consuming CBD
Prior medical consultation
It is strongly recommended to speak with a healthcare professional before starting to consume CBD, especially if you have pre-existing health conditions, are taking other medications, or are pregnant or breastfeeding. 14. Your doctor will be able to assess your specific medical situation, provide you with personalized advice, and help you make informed decisions. 14. Consulting a healthcare professional is especially important if you have a history of specific medical conditions such as liver problems, bleeding disorders, neurological disorders or psychiatric disorders. 14. These conditions may require close monitoring when consuming CBD. 14 .
Dosage and frequency of use
Determining how much CBD to consume is crucial to a positive experience. Several factors affect how much CBD you should take and how to administer it to achieve the desired relief. 15. It is essential to start with a low dose and increase it gradually, depending on your reaction to CBD. 16. Our online CBD dosage calculator can be helpful in helping you determine the appropriate dose based on your weight, height, and the specific characteristics of the product you are using. 15 .
How often you consume CBD also depends on your individual needs. It is advisable to start with a small daily dose and adjust according to the effects you feel. 16. For some, daily use may be beneficial, while others may prefer occasional use, depending on specific circumstances such as stress or insomnia. 16 .
CBD Alternatives for Heart Patients
Risk-Free Options for Heart Patients
For heart patients looking for alternatives to CBD, several dietary supplements can be considered. Among these, omega-3 products, such as Arkogélules Omega 3 and Omegabiane EPA, are recommended to maintain good cardiovascular function. These supplements provide essential fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are known to contribute to normal heart function and help regulate cardiac activity. 17 .
In addition, products like SERELYS Ostéo and Unibiane Resvératrol from Pileje are designed to support cardiovascular health. Resveratrol, in particular, is valued for its beneficial effects on the heart and blood vessels. 17 .
Other food supplements
Other dietary supplements can also be considered safe alternatives for heart patients. For example, Tensiophyt from NATURAL NUTRITION laboratories helps maintain normal blood pressure, while Molval from DIELEN, based on Omega 3 and bioactive peptides, contributes to the proper functioning of the heart and blood vessels. 17 .
Ysonut’s Ubiquinol Complex, which contains ubiquinol as well as vitamins C, E, B3, and B1, is another recommended option to support heart health. As we age, Q10 production declines, making supplementation beneficial for the heart 17 .
These alternatives, by providing essential nutrients and supporting heart function, offer safe options for patients seeking alternatives to CBD for managing their heart health.
Conclusion
At the end of this article, it is clear that while CBD offers undeniable therapeutic benefits, its consumption by patients suffering from heart problems must be surrounded by precautions. We have highlighted the potential risks associated with the use of CBD for these individuals, including interactions with beta-blocker and anticoagulant medications, and the importance of consulting a healthcare professional before its use. This highlights the need for a balanced and informed approach in exploiting the benefits of CBD, without neglecting the contraindications and precautions required to ensure the safety of users.
In summary, although the therapeutic potential of CBD is promising, including for cardiac patients under certain conditions, caution is still required. It is essential to adopt a responsible approach, not losing sight of possible interactions and contraindications. For those who wish to explore the benefits of CBD in a safe setting, it is recommended to turn to trusted products, such as those offered by Hempia, which you can discover here. This carefully measured approach ensures both access to the benefits of CBD and protection of users’ heart health.
FAQs
Is CBD good for the heart?
Research conducted in England in 2019 indicates that taking 600 mg of CBD may lower blood pressure. This effect is attributed to several mechanisms, some of which are still under study.
Who should avoid consuming CBD?
Pregnant and breastfeeding women, people suffering from liver disorders or Parkinson's disease, as well as men wishing to procreate, are advised not to consume CBD.
Is CBD compatible with blood thinning medications?
CBD can act as a blood thinner. Therefore, if you are taking blood thinners, it is crucial to consult your doctor before consuming products containing CBD, as it may alter their effects.
What are the side effects of CBD?
CBD may interact with some medications, increasing the risk of side effects. It is particularly not recommended in cases of liver failure or during antiepileptic treatment with drugs such as valproate or clobazam.
References
[1] - https://blog.hopitalvs.ch/je-fume-du-cbd-quels-sont-les-risks-pour-ma-sante/
[2] - https://originecbd.fr/smartblog/31_origine-cbd.html
[3] - https://cebedia.co/blog/guide/cbd/
[4] - https://www.inserm.fr/actualite/cbd-quel-impact-sur-la-sante/
[5] - https://cebedia.co/affection/cbd-disease-cardiovascular/
[6] - https://www.santelog.com/actualites/cannabidiol-des-effects-eprouvants-sur-le-coeur
[7] - https://www.futura-sciences.com/sante/actualites/coeur-patiente-developpe-immobilier-cardiaque-grave-cause-huile-chanvre-98509/
[8] - https://www.saveurs-cbd.fr/smartblog/176_cbd-medicaments-liste.html
[9] - https://www.msdmanuals.com/fr/accueil/sujets-particuliers/compl%C3%A9ments-alimentaires-et-vitamines/cannabidiol-cbd
[10] - https://uweed.fr/blog/cbd-contre-indication/
[11] - https://www.cbd.fr/blog/interactions-entre-le-cbd-et-les-betaplombs-ce-quil-faut-savoir/
[12] - https://cbdissimo.com/cbd-interactions-medicaments/
[13] - https://www.drogues.gouv.fr/sites/default/files/2022-01/pharmacologie_cbd_vf_-_dec_2021_0.pdf
[14] - https://bonheurdechanvre.com/information/questions-frequentes/dois-je-consulter-mon-medecin-avant-de-prendre-du-cbd
[15] - https://hempia-cbd.com/blogs/dossier-thematique-cbd/combien-de-gouttes-de-cbd-par-jour
[16] - https://www.blubao.fr/blog/quelle-frequence-prendre-cbd
[17] - https://www.easypara.fr/complements-alimentaires/coeur.html
